George Savage is a Silicon Valley-based entrepreneur and investor with a successful track-record of first-in-category medical product innovation. As a founder, board member and C-level executive he has taken several revolutionary ideas through the full lifecycle from conception to funding, development, regulatory approval, commercialisation and exit. Dr Savage pioneered minimally-invasive surgery inside the heart, proceeding from concept to FDA premarket approval in only three years. In 2014, he was named one of the 100 most inspiring people in the pharmaceutical industry by PharmaVoice. In 2016, Dr Savage was elected a fellow of the American Institute of Medical and Biological Engineering “for innovation and medical device entrepreneurship and in advancement of transformative digital health technologies to reduce healthcare cost and improve personalized medicine.”
Dr Savage is currently Co-Founder and Chief Executive Officer of Fulcrum Neuroscience, an AI digital twin company unravelling the causes of neurodegenerative diseases such as Alzheimer’s Dementia.
From 2003 to 2020, Dr Savage was Co-Founder and Chief Medical Officer of Proteus Digital Health, where he demonstrated the power of integrated digital feedback to improve outcomes for patients prescribed oral pharmacotherapy. He won a landmark FDA approval for the first drug-device combination where the innovation was integrated silicon and software rather than novel chemistry or biology.
From 2014-2025, Dr Savage served on the board of the California Life Sciences Association. He has testified to the President’s Commission on Combating Drug Abuse and the Opioid Epidemic and is a frequent keynote speaker on the topic of healthcare innovation. Dr Savage also chairs the Town of Portola Valley Finance Committee.
Passionate about healthcare access in underserved environments, since 2007 Dr Savage volunteers annually as a physician with Ethiopia ACT, meeting medical needs of the poor of Addis Ababa.
George Savage holds degrees in Biomedical Engineering (BS, Boston University), Medicine (MD, Tufts University) and Business (MBA, Stanford University). He is licensed to practice medicine in California, Florida, and in Ethiopia. Dr Savage is a named inventor on more than 50 issued patents.
